Neutron Chareacterization of BNCT Water Phantom Based on 30 MeV Cyclotron Using PHITS Computational Code
DOI:
https://doi.org/10.24246/ijpna.v4i1.22-26Keywords:
cancer, BNCT, Neutron, cyclotron, PHITSAbstract
Cancer is the second leading cause of death globally and was responsible for 8,8 million deaths in 2015. Approximately 70% of deaths from cancer occur in low- and middle-income countries. The war on cancer has been fought with three tools – surgery (cut), radiation therapy (burn) including radiotherapy and bracytherapy, and also chemotherapy (poison). Cancer therapy has increased life expectancy of patients but each treatment modality has its own effects, complications and toxicity. Moreover we have found a new effective method to fight cancer, that is, Boron Neutron Capture Therapy (BNCT). Boron Neutron Capture Therapy (BNCT) has for many decades been advocated as an innovative form of radiotherapy that, in principle, has the potential to be the ideal form of treatment for many types of cancers. This research’s aim is the characterising neutron of BNCT water phantom based on 30 MeV cyclotron using PHITS computational code. The result from the simulation is that thickness of the water phantom, related to flux neutron.
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References
WHO. 2017. Available from:http://www.who.int/mediacentre/factsheets/fs297/en/, accessed on 16/02/2017
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 1J. Ferlay, 1I. Soerjomataram I, 2R. Dikshit, 3S. Eser, 4C. Mathers, 5M. Rebelo, 6D.M. Parkin, 1D. Forman D, 1F. Bray.. international journal of cancer page 1-79, 2015 Mar 1;136(5):E359-86. doi: 10.1002/ijc.29210. Epub 2014 Oct 9
WHO.2014.Cancer Country Profiles
Badan Penelitian Dan Penegembangan Kesehatan Kememnterian Kesehatan RI. 2013.Riset Kesehatran Dasar. Jakarta. Kementerian Kesehatan RI
American Cancer Society. 2017. Cancer Fact and Figures 2017. Atlanta,Georgia. American Cancer Society
Annette and Richard Bloch. 1988. Fighting Cancer. Missouri. R.A. Bloch Cancer Foundation
Michael Lam. 2003. Beating Cancer with Natural Medicine. United States of America. Bloomington,IN
Johanes M. Huitink and Wendy H.L. 2013. Current cancer therapies- Aguide for perioperative physicians. Best Practice & Research Anaesthesiology 2013;27:481-492.
Chirag Shah, Shahed Badiyan, Sameer Berry, Atif J. Khan, Sharagd Goyal, Kevin Schulte, Anish Nanavati, Melanie Lynch, Frank A. Vicini. 2014. Cardiac dose sparing and avoidance techniques in breast cancer radiotherapy. Radiotherapy and Oncology 2014
Sukamal Saha, Gregory Johnston, Alpesh Korant, Mohammed Shaik, Mohammed Kanaan, Rebecca Johnston, Balvant Ganatra, Sunil Kaushal, Dilip Desai, Sreenivas Mannam. 2013. Aberrant drainage of sentinel lymph nodes in colon and its impact on staging and extent of operation. The American Journal of Surgery 2013; 205: 302-306.
Aaro Haapaniemi, Leena Kankaanranta, Riset Saat, Hanna Koivonuro, Kauko Saarilahti, Antii Makitie, Timo Atula, Heikki Joensuu. 2015. Boron Neutron Capture Therapy in the Treatment of Recurrent Laryngeal Cancer. International Journal of Radiation Oncology Biology Physic 2015 ; :1-7
Aaro haapaniemi, Leena Kankaanranta, Riset Saat, Hanna Koivonuro, Kauko Saarilahti, Antii Makitie, Timo Atula, Heikki Joensuu. 2015. Boron Neutron Capture Therapy in the Treatment of Recurrent Laryngeal Cancer. International Journal of Radiation Oncology Biology Physic 2015 ; :1-7
Raymond L. Moss. 2013. Critical review, with an optimistic outlook, on Boron Neutron Capture Therapy (BNCT). Applied Radiation and Isotopes 2013; 88: 2-11.
Micah John Luderer, Pilar de la Puente, Abdel Kareem Azab. 2015. Advancement in Tumor Targeting Strategies for Boron Neutron Capture Therapy. Springer Pharm Res
Elham Bavarnegin, Alireza Sadremomtaz, Hossein Khalafi, Yaser Kasesaz. 2016. Measurement of in‑phantom neutron flux and gamma dose in Tehran research reactor boron neutron capture therapy beam line. Journal of Research and Therapeutics 2016;12:826-9
] Jeng-Ning Wang, Kuo-Wei Lee, Shiang-Huei Jiang. 2013. Effective dose evaluation for BNCT brain tumor treatment based on voxel phantoms. Applied Radiation and Isotopesm 2013;12:012
M.Monshizadeh, Y. Kasesaz, H. Khalafi, S. Hamidi. 2015. MNCP design of thermal and epithermal neutron beam for BNCT at the Isfahan MNSR. Progress in Nuclear Energy 2015; 83 :427-732.
Wolfgang A.G Saurwein. 2012. Principle and Roots of Neutron Capture Therapy. Neuton Capture Therapy Principle and Applications Springer 2012 ; : 1-18
Accelerator-basedBNCT A.J.Kreiner a,b,c,n, M.Baldo a, J.R.Bergueiro a,c, D.Cartelli a,b,c, W.Castell a, V.ThatarVento b, J. GomezAsoia a, D.Mercuri a, J.Padulo a, J.C.SuarezSandin a, J.Erhardt a, J.M.Kesque a, A.A.Valda a,b, M.E.Debray a,b, H.R.Somacal a,b, M.Igarzabal a, D.M.Minsky a,b,c, M.S. Herrera a,b,c, M.E.Capoulat a,b,c, S.J.Gonzalez a,c, M.F.delGrosso a,c, L.Gagetti a,b,c, M. SuarezAnzorena a, M.Gun d, O.Carranza a
Cyclotron-based neutron source for BNCT
T. Mitsumoto, S. Yajima, H. Tsutsui, T. Ogasawara, K. Fujita et al.
Tatsuki Sato, Koji Niita, Norihiro Matsuda, Shintaro Hashimoto, Yosuke Iwamoto, Shusaku Noda, Hiroshi Iwase, Hiroshi Nakashima, Tokio Fukahori, Satoshi Chiba, and Lembit Sihver. 2014. Overview of the PHITS code and its application to medical physics. Progress in Nuclear Science and Technologi 2014 ;4:879-882
Hironuori Horiguchi, Tatsuko Sato, Hiroaki Kumada, Tetsuya Yamamoto and Takeji Sakae. 2014. Estimation of relative biological effectiveness for neutron capture therapy sing the PHITS code coupled with a microdosimetric kinetic model.Journal of Radiation Research 2014:1-9
Tatsuki Sato, Koji Nitta, Norihiro Matsuda, Shintaro Hashimoto, Yosuke Iwamoto, Shusaku Noda, Tatsuhiko Ogawa, Hiroshi Iwase, Hiroshi Nakashima, Tokio Fukahori, Keisuke Okumura, Tetsuya Kai, Satoshi Chiba, Takuya Furuta, Lembit Sihver. 2013. Particle and Heavi Ion Transport code System, PHITS, version 2.52. Journal of Nuclear Science and Technology 2013; 50: 913-923.
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