Dosimetry of in vitro and in vivo Trials in Thermal Column Kartini Reactor for Boron Neutron Capture Therapy (BNCT) facility by using MCNPX Simulator Code

Authors

  • Adrian Tesalonika Department of Physics Engineering, Faculty of Engineering, Universitas Gadjah Mada
  • Andang Widi Harto Department of Physics Engineering, Faculty of Engineering, Universitas Gadjah Mada
  • Yohannes Sardjono Indonesian Nuclear Energy Agency (BATAN)
  • Isman Mulyadi Triatmoko Indonesian Nuclear Energy Agency (BATAN)

DOI:

https://doi.org/10.24246/ijpna.v1i2.63-72

Keywords:

BNCT, in vitro, in vivo, dosimetry, exposure time

Abstract

A dosimetry study of in vitro and in vivo trials system in thermal column of Kartini Reactor for Boron Neutron Capture Therapy (BNCT) facility has been conducted by using the Monte Carlo N-Particle Extended (MCNPX) software. Source of neutron originated from the 100 kW reactor which has been modified by the previous researcher. Models have been made by using simple geometries to represent tissues. Models of in vitro have been made by 4 spheres each has 1 cm diameter to represent tumour, whereas in vivo by 4 cylinders each has 6 cm length, 3 cm diameter, and breast soft tissue material with 1 cm sphere each located in the center of the cylinders to represent models of mouse with tumour. An increase in value of the boron concentration will increase the value of dose rate as well, then the exposure time should be shorter. The exposure times (in minutes) of in vitro trials for 20, 25, 30, 50, 75, 100, 125, and 150 μg boron/g tissues are 117.77, 117.77, 117.07, 115.69, 114.02, 112.39, 110.80, and 109.27. Whereas the exposure times of in vivo trials are 163.58, 162.78, 161.98, 158.88, 155.16, 151.61, 148.22, dan 144.98. In vitro trials have greater values of dose rate so that in vitro trials have shorter exposure time.

Downloads

Download data is not yet available.

References

American Cancer Society. (2014). The Science Behind Radiation Therapy. Retrieved from http://www.cancer.org/acs/groups/cid/documents/webcontent/003019-pdf.pdf

Andang Widi Harto. (n.d.). Metode Monte Carlo, kuliah tanggal 28 Agustus 2014. Yogyakarta: Jurusan Teknik Fisika, Universitas Gadjah Mada.

Bambang Hadi Santoso. (2014). Pemodelan Perisai Radiasi Fasilitas BNCT dengan Sumber Beamport Tembus Teras Reaktor Kartini Menggunakan MCNP5. Yogyakarta: Jurusan Teknik Fisika, Fakultas Teknik, Universitas Gadjah Mada.

D. Rorer, A. Wambersie, G. Whitmore, R. Zamenhof, V. Levin, P. Andreo, & B. Dodd. (2001). Current Status of Neutron Capture Therapy. Vienna: International Atomic Energy Agency.

Denise B. Pelowitz. (2008). MCNPX User's Manual version 2.6.0.

Dwi Berlianti Siwi. (2013). Analisis Dosis di Organ Kritis Pada Terapi Glioblastioma dengan Boron Neutron Capture Therapy Menggunakan Metode Simulasi MCNP5. Yogyakarta: Departemen Teknik FIsika, Fakultas Teknik, Universitas Gadjah Mada.

Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, & et al. (2013). Cancer Incidence and Mortality Worldwide: IARC CancerBase No.11. GLOBOCAN 2012 v1.0. Lyon, France: International Agency for Research on Cancer.

Herman Cember, & Tomas E. Johnson. (2009). Introduction to Health Physics (4th ed.). New York: The McGraw-Hill Companies, Inc.

International Commission on Radiation Unit and Measurements. (1989). Report 44. USA.

Irhas. (2014). Dosimetri Boron Neutron Capture Therapy pada Kanker Hati (Hepatocellular Carcinoma) Menggunakan MCNP-code dengan Sumber Neutron dari Kolom Termal Reaktor Kartini. Yogyakarta: Departemen Teknik Fisika, Fakultas Teknik, Universitas Gadjah Mada.

M.Ilma Muslih Arrozaqi. (2014). Dasar-Dasar Pemrograman MCNPX. Yogyakarta: Pusat Sains dan Teknologi Akselerator Badan Tenaga Nuklir Nasional.

Mugi Wahidin, Rini Noviani, Sofia Hermawan, Vita Andriani, Ardi Ardian, & Hernani Djarir. (2012). Population-Based Cancer Registration in Indonesia. Asian Pacific Journal of Cancer Prevention, 13.

Nicholas Tsoulfanidis. (1995). Measurement and Detection of Radiation. Washington, DC, United States of America: Taylor & Francis.

Nina Fauziah. (2013). A Conceptual Design of Neutron Collimator in The Thermal Column of Kartini Research Reactor for Boron Neutron Capture Therapy. Yogyakarta, Indonesia: Departemen Teknik Fisika, Fakultas Teknik, Universitas Gadjah Mada.

Oxford Dictionaries. (n.d.). Oxford Dictionaries - in vitro. Retrieved September 15, 2015, from http://www.oxforddictionaries.com/definition/english/in-vitro

Oxford Dictionaries. (n.d.). Oxford Dictionaries - in vivo. Retrieved September 15, 2015, from http://www.oxforddictionaries.com/definition/english/in-vivo?q=in+vivo

Ranti Warfi. (2015). Optimasi Kolimator Kolom Termal untuk Fasilitas Uji in vitro dan in vivo BNCT di Reaktor Kartini Menggunakan Simulator MCNP-X. Yogyakarta: Departemen Teknik Fisika, Fakultas Teknik, Universitas Gadjah Mada.

W. A. G. Sauerwein, A. Wittig, R. Moss, & Y. Nakagawa. (2012). Neutron Capture Therapy: Principles and Application. Berlin: Springer-Verlag.

World Health Organization. (2015, Februari). Cancer. Retrieved Juli 13, 2015, from http://www.who.int/mediacentre/factsheets/fs297/en/

Downloads

Published

2016-06-30

How to Cite

Tesalonika, A., Harto, A. W., Sardjono, Y., & Triatmoko, I. M. (2016). Dosimetry of in vitro and in vivo Trials in Thermal Column Kartini Reactor for Boron Neutron Capture Therapy (BNCT) facility by using MCNPX Simulator Code. Indonesian Journal of Physics and Nuclear Applications, 1(2), 63–72. https://doi.org/10.24246/ijpna.v1i2.63-72

Issue

Section

Articles