Assesment of Boron Neutron Capture Therapy (BNCT): Compact Neutron Generators

Authors

  • Nur Setyo Wahyuni
  • Yohannes Sardjono Centre for Accelerator Science and Technology, National Nuclear Energy Agency, Indonesia, Indonesia

DOI:

https://doi.org/10.24246/ijpna.v3i2.36-42

Keywords:

BNCT, CNGs, Neutron Sources, Cancer treatments

Abstract

Boron  Neutron Capture Therapy (BNCT)  is an effective and promising treatment          of tumour types which are resistant to conventional therapies. The characteristics of boron neutron capture therapy (BNCT) for cancer treatment demand, in addition to sufficient fluxes of epithermal neutrons, proper conditions of the neutron sources—compact layout, flexible operation, compatibility with hospital setting, etc. The lack of proper neutron sources that can be integrable to the infrastructure of hospital or clinical facilities is a major problem. Compact neutron generators (CNGs), which are the most compact and least expensive, were a potential, alternative, solution to existing BNCT treatment facilities based on nuclear reactors. This paper will provide information about the latest CNGs technology development that has contributed to the Boron Neutron Capture Therapy (BNCT) technology improvement.

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References

Anonim A., 2012, Neutron generator for analytical purposes, IAEA Radiation Technology Reports Series No. 1, Vienna.

Andreani C., I. S. Anderson, J. M. Carpenter,G. Festa, G. Gorini, C.-K. Loong, andR. Senesi. 2014. Applications Of Compact Accelerator-Driven Neutron Sources: An Updated Assessment From The Perspective Of Materials Research In Italy. Physics Procedia 60 (2014) 228 – 237.

Araujo,Wagner Leite & Campos, T. Passos Ribeiro. 2013. EPITHERMAL NEUTRON BEAM GENERATOR DESIGN FOR BNCT. 22nd International Congress of Mechanical Engineering (COBEM 2013). Ribeirão Preto, SP, Brazil. ISSN 2176-5480.

Asnal M, Liamsuwan T, and Onjun T. 2014. An evaluation on the design of beam shaping assembly based on the D-T reaction for BNCT. Journal of Physics: Conference Series 611(2015) 012031. doi:10.1088/1742-6596/611/1/012031.

Capoulat, M.E., Minsky, D.M., Kreiner, A.J., 2014, Computational assessment of deep-seated tumor treatment capability of the 9Be(d,n)10B reaction for accelerator-based Boron Neutron Capture Therapy (AB-BNCT), Physica Medica 30 (2014) 133-146.

Fantidis, J.G., Saitioti, E., Bandekas, D.V., Vordos, N., 2013, Optimised BNCT facility based on a compact D-D neutron generator, International Journal of Radiation Research, Volume 11, No 4.

Fantidis, J.G., Dimitrios, B.V., Constantinos, P., Nick, V., 2012, Fast and Thermal Neutron Radiographies Based On A Compact Neutron Generator, Theoretical and Applied Physics 2012.

Farghihi, F., 2012, Monte-Carlo Simulation for Beam Shaping Assembly of Boron Neutron Capture Therapy, Proceedings of the 2012 International Conference on Industrial Engineering and Operations Management, Istanbul, Turkey, July 3 – 6, 2012.

Fantidis J.G., and Antoniadis A. 2015. Optimization study for BNCT facility based on a DT neutron generator. International Journal of Radiation Research.January 2015; 13(1): 13-24.

Jenkins, P.A., 2012, Boron Neutron Capture Therapy for Her2+ Breast Cancers: A Feasibility Study Evaluating BNCT for Potential Role in Breast Conservation Therapies, A Dissertation, Department of Civil and Environmental Engineering, The University of Utah, Utah.

Kageji, T., Mizobuchi, Y., Nagahiro, S., Kumada, H., 2011, Clinical result of boron capture therapy (BNCT) for glioblastoma, Applied Radiation and Isotopes 69 (2011) 1823-1825.

K. Bergaoui• N. Reguigui• C. K. Gary•C. Brown• J. T. Cremer• J. H. Vainionpaa•M. A. Piestrup. Prompt gamma-ray neutron activation analysis of boron using Deuterium–Deuterium (D–D) neutron generator. J Radioanal Nucl Chem (2015) 303:115–121.

Kasesaz, Y., Khalafi, H., Rahmani, F., 2013, Optimization of beam shaping assembly in the D-D neutron generator-based BNCT using the response matrix method, Applied Radiation and Isotopes 82 (2013) 55-59.

Koivunoro, Hanna. 2012. Dosimetry and dose planning in boron neutron capture therapy: Monte Carlo studies. (Unpublished master's thesis). Department of Physics Faculty of Science University of Helsinki Helsinki, Finland.

Krstic, D., Markovic, V.M., Jovanovic, Z., Milenkovic, B., Nikezic, D., Atanackovic, J., 2014, Monte Carlo Calculations of Lung Dose in ORNL Phantom for Boron Neutron Capture Therapy, Radiation Protection Dosimetry (2014), Vol. 161, No. 1-4,pp. 269-273.

Leung, K., 2012, Compact Neutron Generator for BNCT, Neutron Capture Therapy, Springer, Berlin.

Loong, C.-K., Sollychin, R., Wong, R.K., Bardley, K., Piestrup, M.A., Liang, T. 2014. The Pros and Cons of Preliminary R&D of Boron Neutron Capture Therapy Based on Compact Neutron Generators: A Plan of Collaboration, Physics Procedia 60 (2014) 264-270.

Miller, A., 2012, Californium-252 as Neutron Source for BNCT, Neutron Capture Therapy, Springer, Berlin.

Moss, R.L., 2014, Critical review, with an optimistic outlook, on Boron Neutron Capture Therapy (BNCT), Applied Radiation and Isotopes 88 (2014) 2-11.

Nakamura, H., Kirihata, M., 2012, Boron Compound: New Candidates for Boron Carriers in BNCT, Neutron Capture Therapy, Springer, Berlin.

Regenfus C., Amsler C., Boccone V., Creus W., and Otyugova P. Operation of a DD-fusion neutron generator in building 15 R-018 for detector R&D in the ArDM project (RE18).

Rasouli, F.S., Masoudi, S.F., 2012a, Design and optimization of a beam shaping assembly for BNCT based on D-T neutron generator and dose evaluation using a simulated head phantom, Applied Radiation and Isotopes 70(2012) 2755-2762.

Rasouli, F.S., Masoudi, S.F., 2012b, Simulation of the BNCT of Brain Tumors Using MCNP Code: Beam designing and Dose Evaluation, Iranian Journal of Medical Physics, Vol. 9, No. 3, Summer 2012, 183-192.

Savolainen, S., Kortesniemi, M., Timonen, M., Reijonen, V., Kuusela, L., Simola, J.U., Salli, E., Koivunoro, H., Seppala, T., Lonnroth, N., Valimaki, P., Hyvonen, H., Kotiluoto, P., Seren, T., Kuronen, A., Heikkinen, S., Kosunen, A., Auterinen, I., 2013, Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences, Physica Medica (2013) 29, 233-248.

Shaaban, I., Albarhoum, M., 2015, Design calculation of an epithermal neutronic beam for BNCT at the Syrian MNSR using the MCNP4 code, Progress in Nuclear energy 78 (2015) 297-302.

Siegel, R., Ma, J., Zou, Z., Jemal, A., 2014, Cancer Statistic 2014, CA Cancer Journal for Clinicians 2014; 64:9-29, American Cancer Society, Atlanta.

Takada, K., Kumada, H., Isobe, T., Terunuma, T., Kamizawa, S., Sakurai, H., sakae, T., Matsumura, A., 2014, Whole-body dose evaluation with an adaptive treatment planning system for boron neutron capture therapy, Radiation Protection Dosimetry (2014), pp. 1-7.

Videira, M., Reis, R.L., Brito, M.A., 2014, Deconstructing breast cancer cell biology and mechanisms of multidrug resistance, Biochimica et Biophysica Acta 1846 (2014) 312-325.

Witig, A., Moss, R.L., Sauerwein, W.A.G., 2014, Glioblastoma, brain metastases and soft tissue sarcoma of extremities: Candidate tumors for BNCT, Applied Radiation and Isotopes 88 (2014) 46-49.

Youlden, D.R., Cramb, S.M., Yip, C.H., Baade, P.D., 2014, Incidence and mortality of female breast cancer in the Asia-Pasific region, Cancer Biol Med 2014;11:101-115.

Zheng Liu, Gang Li, Linmao Liu. 2014. Feasibility of sealed D–T neutron generator as neutron source for liver BNCT and its beam shaping assembly. Applied Radiation and Isotopes 86 (2014) 1–6

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Published

2018-12-11

How to Cite

Wahyuni, N. S., & Sardjono, Y. (2018). Assesment of Boron Neutron Capture Therapy (BNCT): Compact Neutron Generators. Indonesian Journal of Physics and Nuclear Applications, 3(2), 36–42. https://doi.org/10.24246/ijpna.v3i2.36-42

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