Assessment of Analytical Instrumentation for Boron Measurement in BNCT System

  • Isman Mulyadi Triatmoko Center of Science and Technology of Accelerator; National Nuclear Energy Agency
  • Sutjipto Sutjipto Center of Science and Technology of Accelerator; National Nuclear Energy Agency
Keywords: BNCT, QNCR, PGAA, ICP-MS, PET, BDTPS

Abstract

The methods boron measurement in BNCT system has generally progressed with developments in analytical instrumentation. Spectrophotometric methods remained the methods of choice for most routine applications until the development of ICP-OES. ICP-OES was also not adequately sensitive for nutritional and medical research involving animal tissues that are naturally low in boron (B). The development of plasma-source MS (e.g., ICP-MS) not only has overcome most of these drawbacks, but also its capability of measuring B isotopes. The application of nuclear reaction methods (mainly prompt-γ spectrometry) has remained limited to some specialized fields. The validity and comparability of three different analytical techniques (QNCR, PGAA, and ICP-MS) for boron measurement in biological samples and application of these methods for examination of blood and tissue samples from a clinical study on boron uptake in blood, tissue, and neoplastic tissue, after infusion of BPA. The PET-based approach to TPS has been applied in BDTPS and a preliminary evaluation of the correct operation has been performed using a heterogeneous boron phantom, called HEBOM. The validation has been accompanied by calculations done with SERA, following the standard approach. BDTPS needs further in vivo experimental validations.

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References

Bregadze VI, Sivaev IB, Glazun SA (2006) Polyhedral Boron Compounds as Potential Diagnostic and Therapeutic Antitumor Agents. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti- Cancer Agents) 6:75–109

Cerullo N, Daquino G G 2001 CARONTE (1998). A Treatment Planning System Nased on Real Macroscopic Boron Distribution and MCNP-4ª Code: Results and Discussion, Frontiers in Neutron Capture Therapy: Proc. 8th International Symposium on Neutron Capture Therapy (La Jolla, CA, USA, 13- 18 September 1998), Plenum Press, New York, Vol. 1, pp. 225-230

Cerullo N, Daquino G G, Moss R L, Muzi L 2002 Evaluation of the Heterogeneous-Boron-Distribution Influence on the computed dose in BNCT Treatment Planning Systems, Research and Development in Neutron capture Therapy: Proc. 10th Int. Symp. on Neutron Capture Therapy for cancer, (Essen, Germany , 8-13 September 2002), eds W Sauerwein, R Moss A Wittig (Monduzzi Editore), pp. 541-545

Cerullo N, Daquino G G, Muzi L, Esposito J (2004) Nucl. Instr. Meth. B (213), pp. 637-640, Jan. 2004

Chem. Int. Ed. Engl. 40 (2001) 1902.

Christian L. Schütz, (2012), Boron measurement in biological samples - Intercomparison of three analytical methods to assist development of a treatment protocol for neoplastic diseases of the liver with Boron Neutron Capture Therapy, Dissertation zur Erlangung des akademischen Grades, im Promotionsfach Chemie am Fachbereich Chemie, Pharmazie und Geowissenschaften der Johannes Gutenberg-Universität in Mainz

Christian L. Schütz, (2013), Boron Analysis and Boron Imaging in Boron Neutron Capture Therapy, IAEA Technical Meeting on Research Reactor Users' Networks (RRUNs): Advances in Neutron Therapy.

Clarke, W. B.; Koekebakker, M.; Barr, R. D.; Downing, R. G.; Fleming, R. F.(1987), Appl. Radiat. Isotopes (Int. J. Radiat. Appl. Instrum. Part A), 38, 735–747.

D.K. McLemore, D.A. Dixon, S.H. Strauss, Inorg. Chim. Acta 294 (1999) 193.

Daquino G G 2003 PET-based Approach to Treatment Planning Systems: an Improvement toward successful Boron Neutron Capture Therapy (BNCT) (Luxembourg: Office for Official Publications of the European Communities)

Daquino G G, Cerullo C, Mazzini M, Moss R L, Muzi L 2004 Appl Radiat Isot. 61(5) 893-897.

Evans, E. H.; Caruso, J.(1993), A. J. Anal. Ato. Spectrom., 8, 427–431.

Evans, S.; Krahenbuhl, U.(1994) J. Anal. At. Spectrom., 9, 1249–1253.

Gabel D, Holstein H, Larsson B, Gille L, Ericson G, Sacker D, Som P, Fairchild RG (1987) Quantitative Neutron Capture Radiography for Studying the Biodistribution of Tumor-seeking Boron-containing Compounds. Cancer Res 47(20):5451–5454

Gregoire, D. C.(1990) J. Anal. Ato. Spectrom., 5, 623–626.

Hanaoka K, Watabe T, Naka S, et al, FBPA PET in boron neutron capture therapy for cancer: prediction of B concentration in tumor tissue an rat xenograft model. EJNMMI Res, Dec 2014;4(1): 70

Imahori Y, Ueda S, Ohmori Y, Kusuki T, Ono K, Fujii R, Ido T (1998) J. Nucl. Med. 39(2), 325-333

Jarvis, K. E.; Gray, A. L.; Houk,( 1992), R. S. Handbook of Inductively Coupled Plasma Mass Spectrometry.Chapman & Hall, New York.

Johnson, D. A.; Siemer, D. D., Bauer, W. F.(1992) Anal. Chim. Acta, 270, 223–230.

Johnson, P. E.(1989), J. Micronutrient Anal., 6, 59–83.

Jones, L. E.; Thrower, P. A. (1990), Carbon, 28, 239–241.

Kabalka G W, Smith G T, Dike J P, Reid W S, Longford C P D, Robert T G, Reddy N K , Buonocore E, Hübner K F (1997) The Journal of Nuclear Medicine 38 1762-1767

Kempster, P. L.; van Vliet, H. R.; van Staden, J. F.(1989), Anal. Chim. Acta, 218, 69–76.

Lindstrom, R. M.; Byrne, A. R.; Becker, D. A.(1990); Smodis, B.; Garrity, K. M. Fresenius Z. J. Anal.Chem., 338, 569–571.

Lukaszew, R. A.; Marrero, J. G.; Cretella, R. F.; Noutary, C. J.(1990), Analyst, 115, 915–917.

M. Westerhausen, C. Gu¨ ckel, S. Schneiderbauer, H. No¨ th, N.S. Hosmane, Angew.

M.F. Hawthorne, A. Maderna, Chem. Rev. 99 (1999) 3421.

Matsumoto, T.; Aizawa, O.(1990), Appl. Instrum. A, 41, 897–903.

Moore, D. E. (1990) J. Pharm. Biomed. Anal., 8, 547–553.

Moore, D. E. (1990) J. Pharm. Biomed. Anal., 8, 547–553.

Pillay, A. E.; Peisach, M.(1992), Nucl.
Published
2017-02-28
How to Cite
Triatmoko, I., & Sutjipto, S. (2017). Assessment of Analytical Instrumentation for Boron Measurement in BNCT System. Indonesian Journal of Physics and Nuclear Applications, 2(1), 20-33. https://doi.org/https://doi.org/10.24246/ijpna.v2i1.20-33
Section
Articles