Basic Principle Application and Technology of Boron Neutron Capture Cancer Therapy (BNCT) Utilizing Monte Carlo N Particle 5’S Software (MCNP 5) with Compact Neutron Generator (CNG)

  • Aniti Payudan Jendral Soedirman University
  • Abdullah Nur Aziz Jendral Soedirman University
  • Yohannes Sardjono
Keywords: cancer, BNCT, CNG, collimator, neutron

Abstract

The purpose are to know basic principle, needed component, types of compact neutron generator, plus and minus CNG, identify materials can use as collimator, know physics parameters as input software MCNP 5, knowing step simulation with software MCNP 5, dose in BNCT, knowing boron compound that use in BNCT, getting collimator design for BNCT'S application with source is compact neutron generator and count physics parameter of collimator output and compares it with standard IAEA. Method are reading reference and simulation with MCNP 5. The result are BNCT use high linear energy transfer from alpha and lithium as a result of 10B(n,α)7Li reaction. BNCT method is effective for cancer therapy. It is not dangerous to normal tissues. To work perfectly, BNCT needs neutron, boron (BSH and BPA as boron compound) Indonesia have study turmeric as boron compound, neutron source, collimator and dose. Dose component in BNCT that important are dose of recoil proton, dose of gamma, dose alfa and dose radiation to environmentally. CNG produce neutron with fussion reaction of deuterium-deuterium (2,45 MeV), deuterium-tritium (14 MeV), tritium-tritium(11,31 MeV) can used as neutron source BNCT. Many kinds of CNG are axial, coaxial, toroidal, plasma design, accelerator design, and CNG with diameter 2,5 cm. CNG have more benefit than another neutron source, make CNG compatible as BNCT application. Neutron from CNG need collimator to get neutron as IAEA’s parameter.  Material for collimator are wall and aperture (material: Ni, Pb, Bi), moderator (Al, Al2O3, S, AlF3), filter (6Li,10B, LiF, Al, Cd-nat,  Ni-60, BiF3, 157Gd, 151Eu), gamma shield (Bi, Pb). Simulation using MCNP 5 has severally steps, the first is sketching problem, the second is making listing program with notepad, the third open program on visual editor, and the last is running program. Acquired result is design tube collimator with radius 71 cm and high 139, 5 cm. Design contained on lead wall as thick as 19, 5 cm; moderate: heavy water as thick as 4 cm, AlF3 girdle a half of part CNG, MgF 2 (19 cm + 10 cm), Al (6,5 cm + 5 cm);Gamma shield: bismuth, and aperture with diameter 6 cm by steps aside nickel. The result collimator output cross three of five IAEA'S defaults. They are the ratio among dosed gamma with flux epithermal is 5,738×10 -24Gy. cm 2 .n -1, the value of ratio among thermal's neutron flux with epithermal neutron is 0, 02567, and ratio among current with flux neutron completely is 1, 2. Need considerable effort of all part to realize BNCT in Indonesia.

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References

Abeloff, Martin D. Abeloff's Clinical Oncology.4th ed. Philadelphia: Churchill Livingstone, 2008.

Alatas, Z., Hidayati, S., Akhadi, M., Purba,M., Purwadi, D., Ariyanto, S., Winarno, H., Rismiyanto, Sofyatiningrum, E., Hendriyanto, Widyastono, H., Parmanto, E.M., Syahril, tanpa tahun, Buku Pintar Nuklir, BATAN.

Alotiby, Mohammed., 2012, Boron Neutron Capture Therapy for Cancer Treatmens, Disertasi, Univercity Of Surrey.

American Cancer Society. Breast Cancer Facts & Figures 2013-2014. Atlanta: American Cancer Society, Inc. 2013.

Arnold, M., Karim-Kos H. E., Coebergh J.W., Byrnes G., Antilla, A., Ferlay J., Renehan, A.G., Forman, D., Soerjomataram, I., 2013, Recent Trends In Incidence Of Five Common Cancers In 26 European Countries Since 1988: Analysis Of The European, Cancer Observatory, European Journal of Cancer (2015) 51, 1164– 1187.

Athiqoh, F., Budi, W.S., Anam, C., Tjiptono, T.W., 2014, Distribusi Fluks Neutron Sebagai Fungsi BURN-UP Bahan Bakar Reaktor Kartini, ISSN : 2303-7371.

Baidoo, K.E, Yong, K., Brechbiel, M.W., 2012, Molecular Pathways: Targeted a-Particle Radiation Therapy, Published Online First December 10, 2012; DOI: 10.1158/1078-0432.CCR-12-0298.

Barth, R.F., Coderre, J.A., Vicente, M.G., dan Blue, T.E., 2005, Boron Neutron Capture Therapy of Cancer: Current Status and Future Prospects, Clin Cancer Res 2005;11:3987-4002.

Barth,R.F., Soloway, A.H., Fairchild, R.G., 1990, Boron Neutron Capture Therapy of Cancer, Cancer Res 1990;50:1061-1070.

Basdevant, J-L., Rich, J., Spiro, M., 2005, Fundamentals In Nuclear Physics, ISBN 0-387-01672-4.

BATAN, 2014, Peraturan Kepala Badan Tenaga Nuklir Nasional Nomor 16 Tahun 2014, BATAN.

Carter, L.L, Schwarz, R.A., no year, MCNP Visual Editor Computer Code Manual. www.mcnp.vised.com. Diakses pada tanggal 12 Pebruari 2003 oleh BATAN.

Ceballos,C., Esposito,J., Agosteo,S., Colautti,P., Conte,V., Moro,D., Pola,A., 2011, Towards The Final BSA Modeling for The Accelerator-driven BNCT facility at INFN LNL, Applied Radiation and Isotopes 69 (2011) 1660-1663.

Chichester,D.L., dan Simpson,J.D., 2004, Compact Accelerator Neutron Generators, American Institute of Physics.

Copulat, M.E., Minsky, D.M., Kreiner, A.J., 2014, Computational Assessment of Deep-seated Tumor Treatment Capability of The 9Be(d,n)10B Reaction for Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Physica Medica 30 (2014) 133-146.

Durisi,E., Zanini,A., Manfredotti, C., Palamara,F., Sarotto,M., Visca,L., Nastasi,U., 2007, Design of An Epithermal Column for BNCT Based on D-D Fusion neutron Facility, Nuclear Instrument and Method in Physics Research A 574(2007) 363-369.

Eskandari, M.R., Kashian, S., 2009, Design of Moderator and Multiplier Systems for D T Neutron Source in BNCT, Annals of Nuclear Energy 36 (2009) 1100–1102.

Fantidis,J.G., Saitioti,E., Bandekas,D.V., Vordos,N., 2013, Optimised BNCT Facility Based on A Compact D-D Neutron Generator, Int. J. Radiat. Res., October 2013;11(4): 207-214.

Fauziah, N., 2013, A Conceptual Design of Neutron Collimator in The Thermal Column of Kartini Research Reactor for Boron Neutron Capture Therapy, Thesis, Universitas Gadjah Mada, Yogyakrta.

Garabalino, M. A., Hughes, A. M., Molinari, A. J., Heber, E. A., Pozzi, E. C. C., Cardoso, J. E., Colombo, L. Lucas, Nievasm S., Nigg, D. W., Aromando, R. F., Itoiz. M. E., Trivillin, V. A., Schwint, A., 2011, Boron Neutron Capture Therapy (BNCT) for TheTreatment of Liver metastases: Biodistribution studies of boron compounds an experimental model, Radiat Environ Biophys (2011) 50:199–207 DOI 10.1007/s00411-010-0345-6.

Gorey, K.M., Haji-Jama, S., Bartfay, E., Luginnah, I.N., Wright, F.C., Kanjeekal, S.M., 2014, Lack of Access to Chemotherapy for Colon Cancer: Multipicative Disadvantage of Being Exstremely Poor, Inadequately Insured and African American, Health Service Research 2014, 14 :133.

Gritzay, O.O., Kalchenko,O.I., Klimova,N.A., Razbudey,F.V., Sanzhur, A.I., Binney,S.E., 2004, Monte-Carlo Calculations For The Development of A BNCT Neutron Source at The Kyiv Research Reactor, Applied Radiation and Isotopes 61 (2004) 869–873.

Guertin,D.A, Sabatini, D.M., 2005, Cell Size Control, doi: 10.1038/npg.els.0003359.

Gunawan, S., Wolters, E., Dongen, J.V., Ven, P., Sitaresmi, M., Veerman, A., Mantik, M., Kaspers, G., Mostert, S., 2014, Parents’ and Health-Care Providers’ Perspectives on Side- Effects of Childhood Cancer Treatment in Indonesia, Asian Pac J Cancer Prev, 15 (8), 3593-3599.

Harmon,C.D., Busch,.R.D., Briesmeister,J., Forster,R.A., 1994, Criticality Calculations with MCNP: A Primer. LA-12827-M Manual.

Heber, E.M., Kueffer, P.J., Lee Jr, M.W., Wawthorne, F., Garabalino, M.A., Molinari, A.J., Nigg, D.W., Bauer, W., Hughes, A.M., Pozi, E.C.C, Trivillin, V.A., Schwint, A.E., 2012, Boron Delivery with liposome for boron neutron capture Therapy (BNCT): Biodistribution studies an experimental model oral cancer demonstrating therapeutic potential, Radiat Environ Biophys (2012) 51:195–204 DOI 10.1007/s00411-011-0399-0.

Helsinki, 2014, Neutron Capture Therapy, 16th International Congress, Cancer Society of Finland.

Hosmane, N.S., Maguire, J.A., Zhu,Y., Takagaki,M., 2012, Boron and Gadolinium Neutron Capture Therapy for Cancer Treatment, ISBN-13 978-981-4338-67-7.

IAEA,2012, Neutron Generators for Analytical Purposes, International Atomic Energy Agency Vienna, 2012.

IARC, 2013, Latest World Cancer Statistics Global Cancer Burden rises to 14,1 Million New Cases in 2012: Marked Increase in Breast Cancers must be addressed. International Agency for Reasearch on Cancer.

Ilma, M., 2013, Perancangan Kolimator di Beam Port Tembus Reaktor Kartini untuk Boron Neutron Capture Therapy, Skripsi, Universitas Gadjah Mada, Yogyakarta.

Kato,I., Ono,K., Sakurai,Y., Ohmae,M., Maruhashi,A., Imahori,Y., Kirihata,M., Nakazawa,M., Yura,Y., 2004, Effectiveness of BNCT for Recurrent Head and Neck Malignancies , Applied Radiation and Isotopes 61 (2004) 1069–1073.

Kemenkes RI, 2013,Riset Kesehatan Dasar 2013, Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI.

Kim, S., Min, B.J., Yoon, M., Kim, J., Shin, D. H., Lee, S. B., Park, S. Y., Cho, S., Kim, D. H., 2011, Secondary Radiation Doses of Intensity-modulated Radiotherapy and Proton Beam Therapy in Patients with Lung and Liver Cancer, Radiotherapy and Oncology 98 (2011) 335–339.

Krane, S. Kenneth., 1988, Introductory Nuclear Physics, printed in the United States of America, ISBN 0-471-80553-X.

Kristina, S.A., Thavorncharoensap, M., Pongcharoensuk, P., Montakantikul, P., Suansanae, T., Prabandari, Y.S., 2014, Effectiveness of Tobacco Education for Pharmacy Students in Indonesia, Asian Pac J Cancer Prev, 15 (24), 10783-10786.

Lai, H-W., Chien, S-Y., Kuo, S-J., Tseng, L-M., Lin,H-Y., Chi, C-W., Chen, D.R., 2012, The Potential Utility of Curcumin in The Treatment of HER-2-Overexpressed Breast Cancer: An In Vitro and In Vivo Comparison Study with Herceptin, doi:10.1155/2012/486568.

Liu,Y.-W.H, Huang,T.T, Jiang,S.H., Liu,H.M., 2004, Renovation of Epithermal Neutron Beam for BNCT at THOR, Applied Radiation and Isotopes 61 (2004) 1039–1043.

Lou, T.P, 2003. Compact D-D/D-T Neutron Generators and Their Applications, disertasi, University Of California, Berkeley.

Malik, P., Chaundry, N., Mittal, R., Mukherjee, T.K., 2015, Role Of Receptor For Advanced Glycation End Products In The Complication And Progression Of Various Types Of Cancers, Biochimica et Biophysica Acta 1850 (2015) 1898–1904.

Media Nuklir, 2010, Interaksi Neutron, Diakses dari www.media-nuklir.files.wordpress.com/2010/08/interaksineutron.pdf, 8 Agustus 2014.

Mukawa,T., Matsumoto,T., Nita,K., 2011, Study on Microdosimetry for Boron Neutron Capture Therapy, Progress in Nuclear Science And Technology, Vol. 2, pp.242-246 (2011).

Murota, I., dan Obata, T., 2014, Boron Neutron Capture Therapy (BNCT)-Low-Energy Neutron Spectrometer for Neutron Field Characterization, Plasma and Fusion Research: Regular Articles, Volume 9, 4401107 (2014).

NCI, 2009, What You Need To Know About Brain Tumors, U.S. Departement of Health and Human Services, Prancis:National Cancer Institute of Health.

NCI, tanpa tahun, What Is Cancer?, National Cancer Institute at The National Institutes of Health, USA.

NIST, tanpa tahun, www.nist.com. Diakses pada tanggal 15 Agustus 2014.

O’Connor, C.M., Adams, J.U., 2010, Essentials of Cell Biology, Cambridge,MA:NPG Education.

Prevanta, 2012, What is Deuterium ?, http://store.preventawater.com/index.php?route=product/category&path=61_63, diakses pada tanggal 15 Agustus 2014.

R. Gonza´lez-Gonza´ lez, R. Bologna-Molina, N. Molina-Frechero, H. R., 2012, Domı´nguez-Malagon: Prognostic factors and treatment strategies for adult head and neck soft tissue sarcoma. Int. J. Oral Maxillofac. Surg. 2012; 41: 569–575. # 2012, International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Rasouli, F.S., dan Masoudi,S.F., 2012, Simulation of the BNCT of Brain Tumors Using MCNP Code: Beam Designing and Dose Evaluation, Iran J Med Phys, Vol. 9, No. 3, Summer 2012.

Razzeti, A., Farias, R.O., Throp, S.I., Trivillin, V.A., Pozzi., E.C.C., Curotto, P., Schwint, A.E., Gonzalez, S.J., 2013, Design, construction and application of a neutron shield for the treatment of diffuse lung metastases in rats using BNCT, Applied Radiation and Isotopes, http://dx.doi.org/10.1016/j.apradiso.2013.12.021.

Reijonen,J., English,G., Firestone,R., Giquel,F., King,M., Leung,K-N., Sun, M.,,tanpa tahun, Compact Neutron Generator Development at LBNL, Lawrence Berkeley National Laboratory, Berkeley CA, USA.

Reijonen,J., Lou,T.P., Tolmachoff,B., Leung,K-N., 2001, Compact Neutron Source Development at LBNL, Lawrence Berkeley National Laboratory.

Roda, E., Nion, S., Bernochi, G., Coccini, T., 2014, Blood-brain Barrier (BBB) Toxicity and Permeability Assessment after L-(4-10Boronopheny)alanine, A Conventional B-containing drug for Boron Neutron Capture Therapy, Using An In Vitro BBB Model, Brain Research 1583 (2014) 34-44.

Saber,A., Wekken,A.V.D., Hiltermann, T.J.N., Kok, K., Berg, A.V.D., Groen,H.J.M., 2015, Genomic Aberration Guiding Treatment Of Non-Small Cell Lung Cancer Patients, Cancer TreatmentCommunications(2015) 4, 23–33, elsevier.

Sauerwein,W.A.G., dan Moss,R.L., 2009, Requirements for Boron Neutron Capture Therapy (BNCT) at a Nuclear Research Reactor, EUR 23830 EN – 2009.

Saurwein, W.A.G, Wittig, A., Moss, R., Nakagawa, Y., 2012, Neutron Capture Therapy Principles and Applications, ISBN 978-3-642-31334-9.

Savolainen, S., Kortesniemi, M., Timonen, M., Reijonen, V., Kuusela, L., Uusi-Simola,J., Salli, E., Koivonuro, H., Seppala, T., Lonnroth, N., Valimaki, P., Hyvonen, H., Kotiluoto, P., Seren, T., Kuronen, A., Heikkinen, S., Kosunen, A., Auterinen, I., 2012, Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences, Physica Medica (2013) 29, 233e248.

Scorei, I.R., 2011, Boron Compounds in the Breast Cancer Cell Chemoprevention and Chemotherapy, Breast Cancer - Current and Alternative Therapeutic Modalities, Prof. Esra Gunduz (Ed.), ISBN: 978-953-307-776-5, InTech, http://www.intechopen.com/books/breast-cancer-currentand-alternative-therapeutic-modalities/boron-compounds-in-the-breast-cancer-cells-chemoprevention-andchemotherapy.

Shultis, J.K., Faw, R.E., 2011, An MCNP Primer, Kansas State University, Manhattan.

Siegel, R., Ma, J., Zou, Z., Jemal,A., 2014, Cancer Statistics 2014, CA CANCER J CLIN 2014;64:9-29, doi: 10.3322/caac.21208.

Siwi, D.B., 2013, Analisis Dosis Di Organ Kritis Pada Terapi Glioblastoma dengan Boron Neutron Capture Therapy Menggunakan Metode Simulasi MCNP5, Skripsi, Universitas Gadjah Mada, Yogyakarta.

Stupp, R., Masson, W.P., Bent, M.J.V.D., Weller, M., Fisher, B., Taphoom, M.J.B., Belanger, K., Brandes, A.A., Marosi, C., Bogdahn, U., Curschmann,J., Janzer,R., Ludwin, S.K., Gorlia, T., Allgeier, A., Lacombe, D., Cairncross, J.G., Eisenhaur, E., Mirimanoff, R.O., 2005, Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma, N ENGL J MED 352:10.

Trivellin, V.A, Heber, E. M., Itoiz, Nigg, D., Calzetta, O., Blaummann, H., Longhino, J., Schwint, A.E., 2004, Radiobiology of BNCT Mediated by GB-10 and GB-10 +BPA in Experimental Oral Cancer, Applied Radiation and Isotopes 61 (2004) 939–945.

Wahyuningsih, D., 2014, Optimasi Desain Kolimator untuk Uji In Vivo Boron Neutron Capture Therapy (BNCT) pada Beam Port Tembus Reaktor Kartini Menggunakan Simulasi Monte Carlo N Particle 5 (MCNP 5), Thesis, Universitas Gadjah Mada, Yogyakarta.

Wang, C.-K Chrris., 2012, Progress in Californium-252 Neutron Brachytherapy, Brachytherapy, Dr. Kazushi Kishi(Ed.), ISBN: 978-953-51-0602-9.

WHO, 2014, World Health Statistic 2014, World Health Organization (WHO).

Wilken, R., Veena, M.S., Wang, M.B., Srivatsan, E.S., 2011, Curcumin: A Review of Anti-cancer Properties And Therapeutic Activity in Head and Neck Squamous Cell Carcinoma, Molecular Cancer 10:12.

Wu, J., Buggy, D., Fleischmann, E., Parra-Sanchez, I., Treschan, T., Kurz, A., Mascha, E.J., Sessler, D. I., 2015, Thoracic Paravertebral Regional Anesthesia Improves Analgesia After Breast Cancer Surgery: A Randomized Controlled Multicentre Clinical Trial. Can J Anesth/J Can Anesth (2015) 62:241–251, DOI 10.1007/s12630-014-0285-8.

Wu,Y., Ji,Q., Kwan,J., Leung,K-N., 2008, Recent Developments of Compact Neutron Generators at LBNL, Lawrence Berkeley National Laboratory.

X-5 Monte Carlo Team, 2003, MCNP — A General Monte Carlo N-Particle Transport Code, Version 5 Volume I: Overview and Theory, LA-UR-03-1987.

Yanagie, H., 2012, Application of Neutron Capture Therapy for Locally Reccurent Breast Cancer, DOI 10.1007/978-3-642-31334-9_27, © Springer-Verlag Berlin Heidelberg 2012.

Yasui,L., Kroc, T., Gladden, S., Androf, C., Bux, S., Hosmane, N., 2012, Boron Neutron Capture in Prostate Cancer Cells, Applied Radiation and Isotopes 70 (2012) 6–12.

Yu, Dihua dan Hung, M-C., 2007, Breast Cancer Chemosensitivity. ISBN:978-0-387-740379.

Yu, Hui-Ting., Liu, H.Y., Lin, Tzung-Yi, Wang, Ling-Wei., tanpa tahun, BNCT Treatment Planning of Recurrent Head and Neck Cancer Using THORplan,National Tsing Hua University, Hsinchu, Taiwan, R. O. C. dan Taipei Veterans General Hospital, Taipei, Taiwan, R. O. C.

Yura, Y., Fujita, Y., 2013, Boron Neutron Capture Therapy as a Novel Modality of Radiotherapy for Oral Cancer: Principle and anti tumor effect, Oral Science International 10 (2013) 9– 14.
Published
2016-02-28
How to Cite
Payudan, A., Aziz, A., & Sardjono, Y. (2016). Basic Principle Application and Technology of Boron Neutron Capture Cancer Therapy (BNCT) Utilizing Monte Carlo N Particle 5’S Software (MCNP 5) with Compact Neutron Generator (CNG). Indonesian Journal of Physics and Nuclear Applications, 1(1), 20-33. https://doi.org/https://doi.org/10.24246/ijpna.v1i1.20-33
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